© Taylor and Francis
Group
The Journal of Maternal
Fetal & Neonatal Medicine (2021)
DOI 10.1080/14767058.2021.1940933
Received: 16 February 2021
/ Accepted: 4 June 2021
Prenatal diagnosis of isolated perimembranous ventricular septal defects undergoing
primary surgical repair in infancy
Authors
William N Evans,
MD, Ruben J Acherman, MD, Michael L Ciccolo, MD, Juan Lehoux, MD, Humberto
Restrepo, MD, MPH
Source
Children’s Heart
Center Nevada, 3006 S Maryland Parkway, Ste 690, Las Vegas, NV 89109, USA. Email:
WNevans50@aol.com.
Abstract
Objective: We
retrospectively analyzed our center’s experience with the prenatal diagnosis of
isolated perimembranous ventricular septal defects
that underwent primary surgical repair in infancy.
Methods: We
identified patients born in Southern Nevada, between October 2012 and October
2020, with prenatal care that underwent surgical closure of an isolated large perimembranous ventricular septal defect between 1 and 12
months of age. The description at surgery defined ventricular septal defect
morphology. We included only those with situs solitus,
levocardia with-out dextroposition, and without any other cardiovascular
abnormality. We analyzed prenatal detection rates for each of the eight years.
Results: We
identified 81 patients. Of the 81, 35 (43%) had trisomy 21. We identified no
other aneuploidies in those that underwent surgical repair; however, 1 had a 15q13.3 deletion syn-drome,
and 1 had a 22 q11.2 deletion syndrome. Of the 81, 27 (33%) overall were
prenatally diagnosed. Increasing prenatal detection rates strongly correlated
with time (R ¼ 0.92, p ¼ .002).
Conclusions:
Trisomy 21 is common in isolated perimembranous
ventricular septal defects undergoing primary repair in infancy. Further,
prenatal detection rates significantly improved over time, up to 65% detection
in the current years.