© 2008, the Authors
Journal
compilation © 2008, Blackwell Publishing, Inc.
Congenit Heart Dis. 2008;3:299–302
Argatroban Anticoagulation for Cardiac Surgery with
Cardiopulmonary Bypass in an Infant with Double Outlet
Right
Ventricle and a History of Heparin-induced
Thrombocytopenia
Authors
Michael L Ciccolo, MD, Jonathan Bernstein, MD, Juan C Collazos,
MD, Ruben J Acherman, MD, Humberto Restrepo, MD, MPH, James M Winters, CCP, Justin
Krueger, CCP, William N Evans, MD
Source
ChildrenŐs Heart Center Nevada, 3006 S Maryland Pkwy, Ste 690,
Las Vegas, NV 89109 USA.
E-mail: mciccolo@childrensheartcenter.com.
Abstract
Heparin-induced thrombocytopenia (HIT) is a life-threatening
complication of heparin therapy. Anticoagulation inpediatric patients with HIT
is challenging as there are no approved heparin substitutes. We report the use
of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass
in an infant with double outlet rightventricle and a history of HIT.