PRENATAL DIAGNOSIS

PrenatDiagn 2009; 29 : 177–178.

Published online 17 December 2008 in Wiley InterScience

(www.interscience.wiley.com) DOI: 10.1002/pd.2073

Copyright © 2008 John Wiley & Sons, Ltd.

RESEARCH LETTER: Positive maternal anti-SSA/SSB antibody–related fetal right ventricular endocardial fibroelastosis without atrioventricular block, reversal of endocardial fibroelastosis

Authors

Ngeth Pises, MD, Ruben J Acherman, MD, Brian K Iriye, MD, Robert C Rollins, MD, William Castillo, MD, Elizabeth Herceg, MD, William N Evans, MD

Source

Children’s Heart Center Nevada, 3006 S MarylandPkwy, Ste 690, Las Vegas, NV 89109, USA.

Email: IAcherman@aol.com.

Abstract

Positive maternal anti-SSA/SSB antibody–relatedfetal cardiac compromise includes atrioventricular block, sinus bradycardia, myocarditis, cardiomyopathy, and thickening of the endocardium or endocardial fibroelastosis (EFE). EFE may be secondary to intrauterine viral infections, congenital heart disease, or maternal antibodies (Lurie, 1988; Newbould et al., 1991). Maternal antibodyrelated–EFE is usually associated with congenital atrioventricular block (CAVB) (Costedoat–Chalumeauet al., 2003). We report the first prenatal diagnosis of maternal anti-SSA/SSB antibody–associated EFE limited to the right ventricle without atrioventricular block.

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