PRENATAL DIAGNOSIS (2010)
Published online in Wiley InterScience
DOI: 10.1002/pd.2544 (Vol 30, Issue 8, pages 797-799)
Copyright © 2010 John Wiley & Sons, Ltd.
Received: 11 January 2010
Revised: 5 April 2010, Accepted: 7 April 2010
RESEARCH LETTER: Doppler fetal mechanical PR interval prolongation with positive maternal anti-RNP but negative SSA/Ro and SSB/La auto-antibodies
Ruben J Acherman, MD, Deborah M Friedman, Jill P Buyon, Joel Schwartz, William J Castillo, MD, Robert C Rollins, MD, William N Evans, MD
ChildrenŐs Heart Center Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email: IAcherman@aol.com.
Cutaneous neonatal lupus can occur with negative SSA/Ro or SSB/La but positive non-SSA/SSB ribonucleoprotein (RNP) maternal autoantibodies (Provostet al., 1987). No fetal-cardiac manifestations, however, have been reported in association with isolated maternal
RNP autoantibodies. We report the first association of transient first-degree atrioventricular block (AVB) in a fetus exposed to maternal anti-RNP in the absence of SSA/Ro-SSB/La autoantibodies.