Published online in Wiley InterScience

DOI: 10.1002/pd.2544 (Vol 30, Issue 8, pages 797-799)

Copyright © 2010 John Wiley & Sons, Ltd.

Received: 11 January 2010

Revised: 5 April 2010, Accepted: 7 April 2010


RESEARCH LETTER: Doppler fetal mechanical PR interval prolongation with positive maternal anti-RNP but negative SSA/Ro and SSB/La auto-antibodies



Ruben J Acherman, MD, Deborah M Friedman, Jill P Buyon, Joel Schwartz, William J Castillo, MD, Robert C Rollins, MD, William N Evans, MD



ChildrenŐs Heart Center Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email:



Cutaneous neonatal lupus can occur with negative SSA/Ro or SSB/La but positive non-SSA/SSB ribonucleoprotein (RNP) maternal autoantibodies (Provostet al., 1987). No fetal-cardiac manifestations, however, have been reported in association with isolated maternal

RNP autoantibodies. We report the first association of transient first-degree atrioventricular block (AVB) in a fetus exposed to maternal anti-RNP in the absence of SSA/Ro-SSB/La autoantibodies.


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