Cardiology in the Young
2011
doi:10.1017/S1047951110001940
© Cambridge University
Press, 2011
Received: 5 April 2010;
Accepted: 1 December 2010
The changing occurrences of tetralogy of Fallot and simple
transposition of the great
arteries in Southern Nevada
Authors
William N Evans, MD, Ruben J
Acherman, MD, William J Castillo, MD, Humberto Restrepo, MD, MPH
Source
ChildrenŐs Heart Center
Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email: WNevans50@aol.com.
Abstract
We analysed
the occurrence of tetralogy of Fallot and simple transposition in the Hispanic
and non-Hispanic populations of Clark County, Nevada, in the United States of
America over a 30-year period from1980 to 2009. We found a downward trend in
the incidence of simple transposition of the great arteries in the non-Hispanic
population but an upward trend in the incidence in the Hispanic population. For
tetralogy of Fallot, we found an upward trend in the incidence in both
populations; the trend, however, was more dramatic in the Hispanic population.
We also noted differences in the male to female ratios in the different groups.
Eventhough we make no definitive conclusions regarding the causes of these
incidence curves or the differences inoccurrence between males or females, the
data suggest an interplay of genetics and the
environment.