Cardiology in the Young 2011
© Cambridge University Press, 2011
Received: 5 April 2010; Accepted: 1 December 2010
The changing occurrences of tetralogy of Fallot and simple
transposition of the great arteries in Southern Nevada
William N Evans, MD, Ruben J Acherman, MD, William J Castillo, MD, Humberto Restrepo, MD, MPH
ChildrenŐs Heart Center Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email: WNevans50@aol.com.
We analysed the occurrence of tetralogy of Fallot and simple transposition in the Hispanic and non-Hispanic populations of Clark County, Nevada, in the United States of America over a 30-year period from1980 to 2009. We found a downward trend in the incidence of simple transposition of the great arteries in the non-Hispanic population but an upward trend in the incidence in the Hispanic population. For tetralogy of Fallot, we found an upward trend in the incidence in both populations; the trend, however, was more dramatic in the Hispanic population. We also noted differences in the male to female ratios in the different groups. Eventhough we make no definitive conclusions regarding the causes of these incidence curves or the differences inoccurrence between males or females, the data suggest an interplay of genetics and the environment.