Journal
of Neonatal-Perinatal Medicine 2017;10(3):343-346
DOI 10.3233/NPM-16120
Received: 9 September
2016 / Revised: 24 January 2017 / Accepted: 7 March 2017
© 2017 IOS Press and the
Authors
William N Evans, Ruben J Acherman, Ian H Law,
Nicholas H Von Bergen, Ricardo A Samson, Humberto Restrepo
Source
Children’s Heart
Center Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email:
wnevans50@aol.com
Abstract
We describe a
neonate born with complex arrhythmias that included concurrent atrial and
ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN
gene, which codes for titin, a large protein found in striated muscle sarcomeres.
The complex arrhythmias were successfully treated with amiodarone and
flecainide. The patient remains asymptomatic with normal biventricular
function. We speculate that the complex arrhythmias and TTN gene mutation may
be related.