Journal of Neonatal-Perinatal Medicine 2017;10(3):343-346

DOI 10.3233/NPM-16120

Received: 9 September 2016 / Revised: 24 January 2017 / Accepted: 7 March 2017

© 2017 IOS Press and the Authors


Neonatal complex arrhythmias possibly related to a TTN mutation


William N Evans, Ruben J Acherman, Ian H Law, Nicholas H Von Bergen, Ricardo A Samson, Humberto Restrepo



Children’s Heart Center Nevada, 3006 S Maryland Pkwy, Ste 690, Las Vegas, Nevada 89109, USA. Email:



We describe a neonate born with complex arrhythmias that included concurrent atrial and ventricular tachycardias. Genetic testing demonstrated a mutation in the TTN gene, which codes for titin, a large protein found in striated muscle sarcomeres. The complex arrhythmias were successfully treated with amiodarone and flecainide. The patient remains asymptomatic with normal biventricular function. We speculate that the complex arrhythmias and TTN gene mutation may be related.


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