Prenatal Diagnosis 2019;39:1220–1224.

DOI: 10.1177/2045894019876545

Date received: 11 July 2019; Revised: 10 September 2019; Accepted: 19 September 2019

ã 2019 John Wiley & Sons, Ltd.



Persistent right umbilical vein in isomerism


Ruben J. Acherman, MD, William N. Evans, MD



William N. Evans, Children's Heart Center

Nevada, 3006 S. Maryland Pkwy, Ste. 690, Las

Vegas, NV 89109.




Objective: Our objective was to evaluate the incidence of a persistent right umbilical vein in isomerism versus situs solitus.

Methods: For this retrospective, observational, nonrandomized report, we identified fetuses with confirmed right umbilical veins from all patients referred for fetal

echocardiography in Southern Nevada between January 2006 and January 2019.

Results: For the period January 2006 to January 2019, we identified 89 fetuses with situs solitus and a right umbilical vein from 16 320 women undergoing prenatal

cardiac evaluation, resulting in a right umbilical vein incidence of 0.5% in situs solitus. For the same period, we identified 36 fetuses with isomerism and confirmatory

umbilical vein imaging. Of the 36, 15 (42%) had right umbilical veins. Of the15, four of 11 (19%) had left isomerism, and 11 of 15 (73%) had right isomerism(P = .006).

Conclusions: A right umbilical vein is rare with situs solitus and common with isomerism. A right umbilical vein is more common in right isomerism than left isomerism

and should alert the clinician to check for isomeric situs, especially right isomerism.


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